The 26-year-old helped his side set up the mouth-watering tie with their west London rivals by defeating then MK Dons 1-0 in their third round replay on Tuesday. The Hoops won the league clash between the sides at Loftus Road, but the match is remembered for allegations that John Terry aimed racial abuse at Ferdinand. Terry has always denied the allegations.
Asked whether he had any concerns about playing Ferdinand against Chelsea, Hughes said: "No. Obviously I will speak with all the players leading into the game and get an understanding of where they are in their mind in terms of the mentality that you need to go into that game."
He added: "It is a challenging game and a big test for us, but knowing Anton and having seen him over the years I am quite sure he will want to be involved in that game.
"It is a big game anyway because of the opposition and they are near neighbours. We will take it when it presents itself but our focus is very much on the weekend against Wigan."
QPR can welcome back skipper Joey Barton after suspension this weekend. The midfielder watched Tuesday's game and spoke to MK Dons manager Karl Robinson after the match.
"I spoke with Joey downstairs and he was full of praise for the group of players we have got and so was their staff," Robinson said.
"They showed great respect for us and an awful lot of class in the way they got the victory in the end and the way they conducted themselves.
"I think sometimes that goes unnoticed. Footballers get an awful lot of stick at the highest levels for being arrogant, but fair play for their conduct today.
"It will mean a lot to my players, their kind words, and we will take great pride and belief from it."
Source: PA
Source: PA