Shaun Derry is out with a groin problem, Akos Buzsaky has an Achilles complaint, Rob Hulse is sidelined with a knee injury and DJ Campbell is missing to foot damage.
However, Kieron Dyer could return from his foot injury while Adel Taarabt may play despite suffering from a stomach complaint.
Boss Neil Warnock has challenged his side to put up a good challenge in the clash.
"We`d like to give a good account of ourselves and show why we deserve to be in the Premier League," he said.
"It`s great for me as a manager to pit my wits against these teams.
"We`ve got to try and find a way of giving them a game and that`s what we`ve been doing this week."
Manchester City captain Vincent Kompany misses out as he serves a suspension for his sending off against Wolves.
Playmaker David Silva will be assessed after being substituted during the midweek Champions League win at Villarreal with a back injury.
Joleon Lescott is expected to return in place of Kompany with Stefan Savic retaining his spot. Owen Hargreaves will hope to be in contention after a minor calf injury but Carlos Tevez is likely to remain frozen out.
City boss Roberto Mancini knows only too well where the main danger to his side could come from - his former player Shaun Wright-Phillips.
The 30-year-old winger has shone at Loftus Road since leaving City in August in the hope of getting more first-team opportunities.
Wright-Phillips had found chances limited among City's star-studded squad but his departure from the Etihad Stadium was amicable.
Unlike the cases involving Craig Bellamy and Emanuel Adebayor, Mancini still wanted to keep Wright-Phillips in his plans but could not offer any guarantees over appearances.
Mancini said: "I am sure Shaun will want to play very well against us, but I am happy because now he plays in every game - and he deserves that because he is a good guy and a good player.
"We need to pay attention to him on Saturday."
Source: DSG
Source: DSG