Sheffield Wednesday are expected to welcome Jermaine Johnson and Lewis Buxton back into their squad.
Winger Johnson has missed the last three matches with a hamstring strain, while defender Buxton has been out since January with a similar problem.
MATCH PREVIEW
QPR boss Neil Warnock gets the chance to get one over his boyhood club's Sheffield rivals and do his former club Crystal Palace a huge favour.
Warnock has few friends among the Wednesday faithful after his six-and-a-half-year spell as manager of Sheffield United - the team he has always supported.
He is also deeply unpopular with some Palace fans after leaving the troubled south London club to take over at Rangers exactly a month ago.
But an R's victory would be good news for the Eagles, who will climb out of the relegation zone and above Wednesday if they beat Middlesbrough and the Owls fail to win at Loftus Road.
MATCH FACTS
Head-to-head
• QPR are chasing a third successive league win over Wednesday, having won the last two 3-2 and 2-1.
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• The Owls have not won at Loftus Road since October 2000.
Queens Park Rangers
• QPR have drawn their last three league matches and are without a win in five.
• Rangers have kept only four clean sheets all season (and won all four matches).
• More penalties have been converted in Championship matches involving QPR this season than any other club. They have scored five and conceded seven.
Sheffield Wednesday
• Wednesday have not lost in five matches (W1, D4) and have drawn their last three away games.
• They have not won in seven away fixtures, picking up only three points out of 21 since a 2-1 victory at Blackpool on 19 January.
• On-loan forward Luke Varney is one goal short of 50 in his league career.
MOST RECENT MEETING
Sheff Wed 1-2 QPR (Saturday, 7 November 2009)
Wednesday scorer: Johnson 13.
QPR scorers: Simpson 10, Gorkss 82.
Source: BBC Sport
Source: BBC Sport